After he retired following the Fall 2002 semester, Professor W. T. Ingram, who was department chair from 1989-1998, generously set up an endowed fund to be used to bring well-known mathematical scientists to Rolla to give lectures on their work. All Ingram Lectures are open to the entire S&T community, and are widely advertised on campus. Visitors brought here under this program usually give two lectures, one of a general nature and accessible to students, and another more advanced aimed at faculty (though students are certainly welcome). A list of the “Ingram Lecturers” is given below.
Dr. Guowei Wei - Michigan State University
Lecture 1 (general audience presentation): How Math and AI are revolutionizing biosciences
Monday, December 12 at 4:30pm in 204AB Havener
Wei-General-Flyer
Abstract:
Mathematics underpins fundamental theories in physics such as quantum mechanics, general relativity, and quantum field theory. Nonetheless, its success in modern biology, namely cellular biology, molecular biology, biochemistry, genomics, and genetics, has been quite limited. Artificial intelligence (AI) has fundamentally changed the landscape of science, technology, industry, and social media in the past few years and holds a great future for discovering the rules of life. However, AI-based biological discovery encounters challenges arising from the structural complexity of macromolecules, the high dimensionality of biological variability, the multiscale entanglement of molecules, cells, tissues, organs, and organisms, the nonlinearity of genotype, phenotype, and environment coupling, and the excessiveness of genomic, transcriptomic, proteomic, and metabolomic data. We tackle these challenges mathematically. Our work focuses on reducing the complexity, dimensionality, entanglement, and nonlinearity of biological data. We have introduced evolutionary de Rham-Hodge, persistent cohomology, persistent Laplacian, persistent path Laplacian, and persistent sheaf theories to model complex, heterogeneous, multiscale biological systems and thus significantly enhance AI's ability to handle biological data. Using our mathematical AI approaches, my team has been the top winner in D3R Grand Challenges, a worldwide annual competition series in computer-aided drug design and discovery for years. By further integrating with millions of genomes isolated from patients, we reveal the mechanisms of SARS-CoV-2 evolution and transmission and accurately forecast emerging SARS-CoV-2 variants.
Lecture 2 (research presentation): Mechanisms of SARS-CoV-2 Evolution and Transmission
Tuesday, December 13 at 11am in 204AB Havener
Wei-Research-Flyer
Abstract:
Discovering the mechanisms of SARS-CoV-2 evolution and transmission is one of the greatest challenges of our time. By integrating artificial intelligence (AI), viral genomes isolated from patients, tens of thousands of mutational data, biophysics, bioinformatics, and algebraic topology, the SARS-CoV-2 evolution was revealed to be governed by infectivity-based natural selection in early 2020 (J. of Mole. Biol. 2020, 432, 5212-5226). Two key mutation sites, L452 and N501 on the viral spike protein receptor-binding domain (RBD), were predicted in summer 2020, long before they occur in prevailing variants Alpha, Beta, Gamma, Delta, Kappa, Theta, Lambda, Mu, and Omicron. Our recent studies identified a new mechanism of natural selection: antibody resistance (J. Phys. Chem. Lett. 2021, 12, 49, 11850–11857). AI-based forecasting of Omicron’s infectivity, vaccine breakthrough, and antibody resistance was later nearly perfectly confirmed by experiments (J. Chem. Inf. Model. 2022, 62, 2, 412–422). The replacement of dominant BA.1 by BA.2 in later March was foretold in early February (J. Phys. Chem. Lett. 2022, 13, 17, 3840–3849). On May 1, 2022, we projected Omicron BA.4 and BA.5 to become the new dominating COVID-19 variants (arXiv:2205.00532). This prediction became reality in late June. Our models accurately forecast mutational impacts on the efficacy of monoclonal antibodies (mAbs).
Biographical Sketch: Guowei Wei earned his Ph. D. degree from the University of British Columbia in 1996. He was awarded a postdoctoral fellowship from the NSERC of Canada to pursue his postdoctoral work at the University of Houston. In 1998, he joined the faculty of the National University of Singapore and was promoted to Associate Professor in 2001. In 2002, he relocated to Michigan State University, where he is an MSU Foundation Professor of Mathematics, Electrical and Computer Engineering, and Biochemistry and Molecular Biology. His current research interests include mathematical foundations of data science and biosciences, deep learning, drug discovery, and computational geometry, topology, and graph. Dr. Wei has served extensively in a wide variety of national and international panels, committees, and journal editorships. His work was reported in numerous news and media articles.